Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans-Reference-Cited by-同舟云学术

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

Published:2018-05-18 Issue:11 Volume:46 Page:1756-1766
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Yamasaki Yuki,Kobayashi Kaoru,Okuya Fuka,Kajitani Naoyo,Kazuki Kanako,Abe Satoshi,Takehara Shoko,Ito Shingo,Ogata Seiryo,Uemura Tatsuki,Ohtsuki Sumio,Minegishi Genki,Akita Hidetaka,Chiba Kan,Oshimura Mitsuo,Kazuki Yasuhiro

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference48 articles.

1. Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology;Abe;Sci Rep,2017

2. Quantitative targeted absolute proteomics of transporters and pharmacoproteomics-based reconstruction of P-glycoprotein function in mouse small intestine;Akazawa;Mol Pharm,2016

3. Role of transport proteins in drug absorption, distribution and excretion

4. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

5. Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein;Bardelmeijer;Clin Cancer Res,2000

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special populations, and the blood-brain barrier;Drug Metabolism Reviews;2024-07-05

2. Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery;Drug Metabolism and Pharmacokinetics;2024-06

3. Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics;Pharmacology Research & Perspectives;2024-04-21

4. Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation;Pharmacogenetics and Genomics;2022-08-22

5. Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors;Journal of Pharmacology and Experimental Therapeutics;2022-08-05