The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation-Reference-Cited by-同舟云学术

The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation

Published:2019-01-23 Issue:4 Volume:47 Page:358-363
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Bowman Christine M.,Okochi Hideaki,Benet Leslie Z.^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference53 articles.

1. Baik J Huang Y (2015) Transporter-induced protein binding shift (TIPBS) hypothesis and modeling, in 20th North American ISSX Meeting. Orlando, Florida, October 2015.

2. Facilitation by serum albumin of renal tubular secretion of organic anions;Besseghir;Am J Physiol,1989

3. Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations

4. Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

5. Plasma protein binding: From discovery to development

Cited by 49 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Drug transporters in drug disposition – highlights from the year 2023;Drug Metabolism Reviews;2024-09-11

2. An Overview of Interpretability of Two Models of Unbound Fraction that are Used in Combination with the Well-Stirred Model for Predicting Hepatic Clearance of Drugs;Journal of Pharmaceutical Sciences;2024-09

3. Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake;Drug Metabolism and Disposition;2024-04-11

4. Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran;Pharmacological Reports;2024-03-26

5. Building a Predictive PBPK Model for Human OATP Substrates: a Strategic Framework for Early Evaluation of Clinical Pharmacokinetic Variations Using Pitavastatin as an Example;The AAPS Journal;2024-01-05