The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping-Reference-Cited by-同舟云学术

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The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

Published:2004-08-12 Issue:5 Volume:66 Page:1201-1212
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Witchel Harry J.,Dempsey Christopher E.,Sessions Richard B.,Perry Matthew,Milnes James T.,Hancox Jules C.,Mitcheson John S.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference33 articles.

1. Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels

2. Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome: Insights from a CoMFA Study of HERG K+ Channel Blockers

3. Stacking and T-shape Competition in Aromatic−Aromatic Amino Acid Interactions

4. Propafenone Preferentially Blocks the Rapidly Activating Component of Delayed Rectifier K + Current in Guinea Pig Ventricular Myocytes

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1. Drug-Induced QT Prolongation;Reference Module in Biomedical Sciences;2024

2. Structural modeling of hERG channel–drug interactions using Rosetta;Frontiers in Pharmacology;2023-11-14

3. Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue;Pharmaceuticals;2023-08-24

4. Calculations of the binding free energies of the Comprehensive <i>in vitro</i> Proarrhythmia Assay (CiPA) reference drugs to cardiac ion channels;Biophysics and Physicobiology;2023

5. Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker;Molecular Pharmacology;2022-08-30

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