Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody-Reference-Cited by-同舟云学术

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Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody

Published:2022-12-02 Issue:3 Volume:51 Page:403-412
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Datta-Mannan Amita,Molitoris Bruce A.,Feng Yiqing,Martinez Michelle M.,Sandoval Ruben M.,Brown Robin M.,Merkel Daniel,Croy Johnny E.,Dunn Kenneth W.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference45 articles.

1. Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

2. An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2

3. Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer;Boswell;Oncotarget,2019

4. Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

5. Tracking antibody distribution with near-infrared fluorescent dyes: impact of dye structure and degree of labeling on plasma clearance;Cilliers;Mol Pharm,2017

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1. Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals;PLOS ONE;2024-04-17

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