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Effects of Endogenous Steroids on CYP3A4-Mediated Drug Metabolism by Human Liver Microsomes

  • Published:2002-05-01 Issue:5 Volume:30 Page:534-540
  • ISSN:0090-9556
  • Container-title:Drug Metabolism and Disposition
  • language:en
  • Short-container-title:Drug Metab Dispos

Author:

Nakamura Hiroyoshi,Nakasa Hiromitsu,Ishii Itsuko,Ariyoshi Noritaka,Igarashi Takashi,Ohmori Shigeru,Kitada Mitsukazu

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference31 articles.

1. Cortisol metabolism in vitro—III. Inhibition of microsomal 6β—hydroxylase and cytosolic 4-ene-reductase

2. Diazepam metabolism by human liver microsomes is mediated by both S- mephenytoin hydroxylase and CYP3A isoforms.

3. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.;Domanski;J Pharmacol Exp Ther,2000

4. Age and gender influence the stereoselective pharmacokinetics of propranolol.;Gilmore;J Pharmacol Exp Ther,1992

5. Analysis of human cytochrome P450 3A4 cooperativity: Construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

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