Metabolism of [14C]GSK977779 in Rats and Its Implication with the Observed Covalent Binding-Reference-Cited by-同舟云学术

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Metabolism of [14C]GSK977779 in Rats and Its Implication with the Observed Covalent Binding

Published:2011-05-31 Issue:9 Volume:39 Page:1620-1632
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Tsalta Catherine D.,Madatian Armina,Schubert Ernest M.,Xia Fangming,Hardesty William M.,Deng Yanli,Seymour Jennifer L.,Gorycki Peter D.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference29 articles.

1. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity

2. Chemical and Immunochemical Comparison of Protein Adduct Formation of Four Carboxylate Drugs in Rat Liver and Plasma

3. Interspeciesin vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

4. Covalent binding of an intermediate(s) in prostaglandin biosynthesis to guinea pig lung microsomal protein

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1. Bioisosterism: 1,2,4‐Oxadiazole Rings;ChemMedChem;2023-03-02

2. Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans;Regulatory Toxicology and Pharmacology;2023-03

3. Experimental Evaluation of 3-meta-Pyridine-1,2,4-Oxadiazole Derivative of Deoxycholic Acid as a Prototype of 5-α-Reductase Inhibitors in In Silico and In Vivo Models;Russian Journal of Bioorganic Chemistry;2023-02

4. Experimental Assessment of 3-<i>meta</i>-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors <i>in silico</i> and <i>in vivo</i> Models;Биоорганическая химия;2023-01-01

5. Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies;Drug Metabolism and Pharmacokinetics;2022-08

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