Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
Author:
Affiliation:
1. Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01478
Reference51 articles.
1. Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily
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4. Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes.
5. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2
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