Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor
Author:
Affiliation:
1. ArQule Inc., One Wall Street, Burlington, Massachusetts 01803, United States
2. Daiichi Sankyo Co., Shinagawa R&D Center, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00619
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1. PKB/AKT: functional insights from genetic models
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5. The PI3K/AKT Pathway as a Target for Cancer Treatment
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