PKB/AKT: functional insights from genetic models
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/35096067.pdf
Reference94 articles.
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3. Bellacosa, A., Testa, J. R., Staal, S. P. & Tsichlis, P. N. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254, 274?277 (1991).
4. Okano, J., Gaslightwala, I., Birnbaum, M. J., Rustgi, A. K. & Nakagawa, H. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J. Biol. Chem. 275, 30934?30942 (2000).
5. Alessi, D. R. et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541?6551 (1996).Identification of the phosphorylation mechanism of PKB/AKT activation (at Thr308 and Ser473), initiating the hunt for upstream kinases.
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