Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4-Reference-Cited by-同舟云学术

Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4

Published:2017-03-24 Issue:7 Volume:60 Page:2732-2744
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Małuch Izabela¹,Levesque Christine²³,Kwiatkowska Anna²³^ORCID,Couture Frédéric²³,Ly Kévin²³,Desjardins Roxane²³,Neugebauer Witold A.²,Prahl Adam¹,Day Robert²³

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland

2. Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke J1H 5N4, Canada

3. Département de Chirurgie/Urologie, Centre Hospitalier Université de Sherbrooke, 3001 12e Avenue Nord, J1H 5N4 Sherbrooke, Canada

Funder

Canadian Institutes of Health Research

Movember Foundation

Narodowe Centrum Nauki

Prostate Cancer Canada

Canadian Cancer Society Research Institute

Fondation Mon ?toile

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01499

Reference50 articles.

1. The biology and therapeutic targeting of the proprotein convertases

2. On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications

3. Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition

4. Curbing activation: proprotein convertases in homeostasis and pathology

5. Furin at the cutting edge: From protein traffic to embryogenesis and disease

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host–Guest Inclusion Complex with β-Cyclodextrin;Molecular Pharmaceutics;2023-08-09

2. Label-Free Electrochemical Test of Protease Interaction with a Peptide Substrate Modified Gold Electrode;Chemosensors;2021-07-29

3. Design and Structure–Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin;ACS Medicinal Chemistry Letters;2021-02-05

4. Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug;Scientific Reports;2019-02-14

5. Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue;Journal of Medicinal Chemistry;2018-12-01