Design and Structure–Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin-Reference-Cited by-同舟云学术

Design and Structure–Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin

Published:2021-02-05 Issue:3 Volume:12 Page:365-372
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lewandowska-Goch Monika A.¹,Kwiatkowska Anna²³^ORCID,Łepek Teresa¹,Ly Kévin⁴,Navals Pauline²³⁵,Gagnon Hugo⁴,Dory Yves L.²⁵^ORCID,Prahl Adam¹,Day Robert²³^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland

2. Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada

3. Département de Chirurgie/Urologie, Faculté de Médecine et Sciences de la Santé, Centre Hospitalier Universitaire de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada

4. PhenoSwitch Bioscience Inc., 975 rue Léon-Trépanier, Sherbrooke, Quebec J1G 5J6, Canada

5. Département de Chimie, Faculté des Sciences, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada

Funder

Canadian Institutes of Health Research

Narodowe Centrum Nauki

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00386

Reference34 articles.

1. The activation and physiological functions of the proprotein convertases

2. The biology and therapeutic targeting of the proprotein convertases

3. Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificity

4. Proprotein convertases: lessons from knockouts

5. Limited Redundancy of the Proprotein Convertase Furin in Mouse Liver

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