Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host–Guest Inclusion Complex with β-Cyclodextrin-Reference-Cited by-同舟云学术

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Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host–Guest Inclusion Complex with β-Cyclodextrin

Published:2023-08-09 Issue:9 Volume:20 Page:4559-4573
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Navals Pauline¹^ORCID,Kwiatkowska Anna²^ORCID,Mekdad Nawel²,Couture Frédéric²,Desjardins Roxane²,Day Robert³,Dory Yves L.¹^ORCID

Affiliation:

1. Institut de Pharmacologie de Sherbrooke, Département de Chimie, Faculté des Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada

2. Institut de Pharmacologie de Sherbrooke, Département de Chirurgie/Urologie, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada

3. Phenoswitch Bioscience Inc, 975 Rue Léon-Trépanier, Sherbrooke, Québec J1G 5J6, Canada

Funder

Canadian Institutes of Health Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00261

Reference63 articles.

1. The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions

2. On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications

3. Molecular Validation of PACE4 as a Target in Prostate Cancer

4. The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells

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