Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Author:
Affiliation:
1. Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States
2. Aptinyx, 1801 Maple Avenue, No. 4300, Evanston, Illinois 60201, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00063
Reference29 articles.
1. Voltage-gated sodium channel blockers for the treatment of neuropathic pain
2. Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
3. Pain Disorders and Erythromelalgia Caused by Voltage-Gated Sodium Channel Mutations
4. From genes to pain: Nav1.7 and human pain disorders
5. Channelopathies have many faces
Cited by 26 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation;Pharmaceutics;2024-07-27
2. Design and synthesis of fused azacyclic and azaspirocyclic γ-lactams targeting dopaminergic D2/D4 receptors;Journal of Molecular Structure;2024-03
3. Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity;European Journal of Medicinal Chemistry;2023-02
4. Indazolones Directed Rh(III)‐Catalyzed C−H Amidation of Arenes;Advanced Synthesis & Catalysis;2022-09-06
5. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain;Bioorganic & Medicinal Chemistry;2022-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3