Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain-Reference-Cited by-同舟云学术

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain

Published:2022-06 Issue: Volume:63 Page:116743
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Patel Meena V.,Peltier Hillary M.,Matulenko Mark A.,Koenig John R.,C. Scanio Marc J.,Gum Rebecca J.,El-Kouhen Odile F.,Fricano Meagan M.,Lundgaard Greta L.,Neelands Torben,Zhang Xu-Feng,Zhan Cenchen,Pai Madhavi,Ghoreishi-Haack Nayereh,Hudzik Thomas,Gintant Gary,Martin Ruth,McGaraughty Steve,Xu Jun,Bow Daniel,Kalvass John C.,Kym Philip R.,DeGoey David A.,Kort Michael E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference38 articles.

1. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update;Dworkin;Mayo Clin Proc,2010

2. Recent progress in sodium channel modulators for pain;Bagal;Biorg Med Chem Lett,2014

3. Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations;Dabby;Curr Neurol Neurosci Rep,2012

4. From genes to pain: Nav1.7 and human pain disorders;Dib-Hajj;Trends Neurosci,2007

5. Neuroscience: Channelopathies have many faces;Waxman;Nature,2011

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