In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin-Reference-Cited by-同舟云学术

In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin

Published:2016-11-29 Issue:23 Volume:59 Page:10763-10773
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chauhan Vinita¹,Chaudhary Dilip¹,Pathak Uma¹,Saxena Nandita¹,Dhaked Ram Kumar¹

Affiliation:

1. Biotechnology Division, ‡Synthetic Chemistry Division, and §Pharmacology and Toxicology Division, Defence Research and Development Establishment, Gwalior 474002, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01517

Reference25 articles.

1. Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1

2. Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli.

3. Approaches to treatment of emerging Shiga toxin-producing Escherichia coli infections highlighting the O104:H4 serotype

4. Structure, biological functions and applications of the AB5 toxins

5. Retrograde trafficking of AB5 toxins: mechanisms to therapeutics

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