Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain

Author:

Muratspahić Edin1,Tomašević Nataša1,Koehbach Johannes2ORCID,Duerrauer Leopold13,Hadžić Seid1,Castro Joel45,Schober Gudrun45,Sideromenos Spyridon6,Clark Richard J.3ORCID,Brierley Stuart M.457,Craik David J.2ORCID,Gruber Christian W.1ORCID

Affiliation:

1. Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

2. Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia

3. School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia

4. Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia 5042, Australia

5. Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia

6. Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria

7. Discipline of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia

Funder

Austrian Science Fund

National Health and Medical Research Council

Australian Research Council

Bundesministerium f??r Bildung, Wissenschaft und Forschung

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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