Harnessing cyclotides to design and develop novel peptide GPCR ligands-Reference-Cited by-同舟云学术

Harnessing cyclotides to design and develop novel peptide GPCR ligands

Published:2020 Issue:4 Volume:1 Page:177-191
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Muratspahić Edin¹²³⁴⁵^ORCID,Koehbach Johannes⁵⁶⁷⁸⁹^ORCID,Gruber Christian W.¹²³⁴^ORCID,Craik David J.⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. Center for Physiology and Pharmacology

2. Institute of Pharmacology

3. Medical University of Vienna

4. Austria

5. Institute for Molecular Bioscience

6. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science

7. The University of Queensland

8. Brisbane

9. Australia

Abstract

Cyclotides are plant-derived cyclic peptides that have emerged as promising scaffold molecules for designing peptide-based therapeutics. Cyclotide engineering may lead to the development of novel ligands of G protein-coupled receptors with improved pharmacological properties.

Funder

National Health and Medical Research Council

Austrian Science Fund

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CB/D0CB00062K

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