Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

Author:

Ashhurst Anneliese S.12,Tang Arthur H.1,Fajtová Pavla34,Yoon Michael C.3ORCID,Aggarwal Anupriya5,Bedding Max J.1,Stoye Alexander1,Beretta Laura3,Pwee Dustin3,Drelich Aleksandra6,Skinner Danielle3,Li Linfeng7ORCID,Meek Thomas D.7ORCID,McKerrow James H.3,Hook Vivian3,Tseng Chien-Te6,Larance Mark8ORCID,Turville Stuart5,Gerwick William H.39,O’Donoghue Anthony J.3,Payne Richard J.110ORCID

Affiliation:

1. School of Chemistry, The University of Sydney, Sydney, NSW2006, Australia

2. School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW2006, Australia

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093, United States

4. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610Prague, Czech Republic

5. Kirby Institute, University of New South Wales, Sydney, NSW2052, Australia

6. Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas77755-1001, United States

7. Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas77843, United States

8. Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW2006, Australia

9. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California92093, United States

10. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW2006, Australia

Funder

National Health and Medical Research Council

Cancer Institute NSW

Fogarty International Center, International Cooperative Biodiversity Group program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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