Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Author:

Voysey Merryn,Clemens Sue Ann Costa,Madhi Shabir A,Weckx Lily Y,Folegatti Pedro M,Aley Parvinder K,Angus Brian,Baillie Vicky L,Barnabas Shaun L,Bhorat Qasim E,Bibi Sagida,Briner Carmen,Cicconi Paola,Collins Andrea M,Colin-Jones Rachel,Cutland Clare L,Darton Thomas C,Dheda Keertan,Duncan Christopher J A,Emary Katherine R W,Ewer Katie J,Fairlie Lee,Faust Saul N,Feng Shuo,Ferreira Daniela M,Finn Adam,Goodman Anna L,Green Catherine M,Green Christopher A,Heath Paul T,Hill Catherine,Hill Helen,Hirsch Ian,Hodgson Susanne H C,Izu Alane,Jackson Susan,Jenkin Daniel,Joe Carina C D,Kerridge Simon,Koen Anthonet,Kwatra Gaurav,Lazarus Rajeka,Lawrie Alison M,Lelliott Alice,Libri Vincenzo,Lillie Patrick J,Mallory Raburn,Mendes Ana V A,Milan Eveline P,Minassian Angela M,McGregor Alastair,Morrison Hazel,Mujadidi Yama F,Nana Anusha,O’Reilly Peter J,Padayachee Sherman D,Pittella Ana,Plested Emma,Pollock Katrina M,Ramasamy Maheshi N,Rhead Sarah,Schwarzbold Alexandre V,Singh Nisha,Smith Andrew,Song Rinn,Snape Matthew D,Sprinz Eduardo,Sutherland Rebecca K,Tarrant Richard,Thomson Emma C,Török M Estée,Toshner Mark,Turner David P J,Vekemans Johan,Villafana Tonya L,Watson Marion E E,Williams Christopher J,Douglas Alexander D,Hill Adrian V S,Lambe Teresa,Gilbert Sarah C,Pollard Andrew J,Aban Marites,Abayomi Fatola,Abeyskera Kushala,Aboagye Jeremy,Adam Matthew,Adams Kirsty,Adamson James,Adelaja Yemi A.,Adewetan Gbadebo,Adlou Syed,Ahmed Khatija,Akhalwaya Yasmeen,Akhalwaya Saajida,Alcock Andrew,Ali Aabidah,Allen Elizabeth R.,Allen Lauren,Almeida Thamires C. D. S. C,Alves Mariana P.S.,Amorim Fabio,Andritsou Foteini,Anslow Rachel,Appleby Matthew,Arbe-Barnes Edward H.,Ariaans Mark P.,Arns Beatriz,Arruda Laiana,Azi Paula,Azi Lorena,Babbage Gavin,Bailey Catherine,Baker Kenneth F.,Baker Megan,Baker Natalie,Baker Philip,Baldwin Lisa,Baleanu Ioana,Bandeira Danieli,Bara Anna,Barbosa Marcella A.S.,Barker Debbie,Barlow Gavin D.,Barnes Eleanor,Barr Andrew S.,Barrett Jordan R.,Barrett Jessica,Bates Louise,Batten Alexander,Beadon Kirsten,Beales Emily,Beckley Rebecca,Belij-Rammerstorfer Sandra,Bell Jonathan,Bellamy Duncan,Bellei Nancy,Belton Sue,Berg Adam,Bermejo Laura,Berrie Eleanor,Berry Lisa,Berzenyi Daniella,Beveridge Amy,Bewley Kevin R.,Bexhell Helen,Bhikha Sutika,Bhorat Asad E.,Bhorat Zaheda E.,Bijker Else,Birch Geeta,Birch Sarah,Bird Adam,Bird Olivia,Bisnauthsing Karen,Bittaye Mustapha,Blackstone Katherine,Blackwell Luke,Bletchly Heather,Blundell Caitlin L.,Blundell Susannah R.,Bodalia Pritesh,Boettger Bruno C.,Bolam Emma,Boland Elena,Bormans Daan,Borthwick Nicola,Bowring Francesca,Boyd Amy,Bradley Penny,Brenner Tanja,Brown Phillip,Brown Claire,Brown-O'Sullivan Charlie,Bruce Scott,Brunt Emily,Buchan Ruaridh,Budd William,Bulbulia Yusuf A.,Bull Melanie,Burbage Jamie,Burhan Hassan,Burn Aileen,Buttigieg Karen R.,Byard Nicholas,Cabera Puig Ingrid,Calderon Gloria,Calvert Anna,Camara Susana,Cao Michelangelo,Cappuccini Federica,Cardoso João R.,Carr Melanie,Carroll Miles W.,Carson-Stevens Andrew,Carvalho Yasmin de M.,Carvalho José A.M.,Casey Helen R.,Cashen Paul,Castro Thais,Castro Lucia Carratala,Cathie Katrina,Cavey Ana,Cerbino-Neto José,Chadwick Jim,Chapman David,Charlton Sue,Chelysheva Irina,Chester Oliver,Chita Sunder,Cho Jee-Sun,Cifuentes Liliana,Clark Elizabeth,Clark Matthew,Clarke Andrea,Clutterbuck Elizabeth A.,Collins Sarah L.K.,Conlon Christopher P.,Connarty Sean,Coombes Naomi,Cooper Cushla,Cooper Rachel,Cornelissen Lynne,Corrah Tumena,Cosgrove Catherine,Cox Tony,Crocker Wendy E.M.,Crosbie Sarah,Cullen Lorraine,Cullen Dan,Cunha Debora R.M.F.,Cunningham Christina,Cuthbertson Fiona C.,Da Guarda Suzete N. Farias,da Silva Larissa P.,Damratoski Brad E.,Danos Zsofia,Dantas Maria T.D.C.,Darroch Paula,Datoo Mehreen S.,Datta Chandrabali,Davids Malika,Davies Sarah L.,Davies Hannah,Davis Elizabeth,Davis Judith,Davis John,De Nobrega Maristela M.D.,De Oliveira Kalid Lis Moreno,Dearlove David,Demissie Tesfaye,Desai Amisha,Di Marco Stefania,Di Maso Claudio,Dinelli Maria I.S.,Dinesh Tanya,Docksey Claire,Dold Christina,Dong Tao,Donnellan Francesca R.,Dos Santos Tannyth,dos Santos Thainá G.,Dos Santos Erika Pachecho,Douglas Naomi,Downing Charlotte,Drake Jonathan,Drake-Brockman Rachael,Driver Kimberley,Drury Ruth,Dunachie Susanna J.,Durham Benjamin S.,Dutra Lidiana,Easom Nicholas J.W.,van Eck Samual,Edwards Mandy,Edwards Nick J.,El Muhanna Omar M.,Elias Sean C.,Elmore Mike,English Marcus,Esmail Alisgair,Essack Yakub Moosa,Farmer Eoghan,Farooq Mutjaba,Farrar Madi,Farrugia Leonard,Faulkner Beverley,Fedosyuk Sofiya,Felle Sally,Feng Shuo,Ferreira Da Silva Carla,Field Samantha,Fisher Richard,Flaxman Amy,Fletcher James,Fofie Hazel,Fok Henry,Ford Karen J.,Fowler Jamie,Fraiman Pedro H.A.,Francis Emma,Franco Marilia M.,Frater John,Freire Marilúcia S.M.,Fry Samantha H.,Fudge Sabrina,Furze Julie,Fuskova Michelle,Galian-Rubio Pablo,Galiza Eva,Garlant Harriet,Gavrila Madita,Geddes Ailsa,Gibbons Karyna A.,Gilbride Ciaran,Gill Hardeep,Glynn Sharon,Godwin Kerry,Gokani Karishma,Goldoni Ursula Carvalho,Goncalves Maria,Gonzalez Isabela G.S.,Goodwin Jayne,Goondiwala Amina,Gordon-Quayle Katherine,Gorini Giacomo,Grab Janet,Gracie Lara,Greenland Melanie,Greenwood Nicola,Greffrath Johann,Groenewald Marisa M.,Grossi Leonardo,Gupta Gaurav,Hackett Mark,Hallis Bassam,Hamaluba Mainga,Hamilton Elizabeth,Hamlyn Joseph,Hammersley Daniel,Hanrath Aidan T.,Hanumunthadu Brama,Harris Stephanie A.,Harris Clair,Harris Tara,Harrison Thomas D.,Harrison Daisy,Hart Thomas C.,Hartnell Birgit,Hassan Shadin,Haughney John,Hawkins Sophia,Hay Jodie,Head Ian,Henry John,Hermosin Herrera Macarena,Hettle David B.,Hill Jennifer,Hodges Gina,Horne Elizea,Hou Mimi M.,Houlihan Catherine,Howe Elizabeth,Howell Nicola,Humphreys Jonathan,Humphries Holly E.,Hurley Katrina,Huson Claire,Hyder-Wright Angela,Hyams Catherine,Ikram Sabina,Ishwarbhai Alka,Ivan Monica,Iveson Poppy,Iyer Vidyashankara,Jackson Frederic,De Jager Jeanne,Jaumdally Shameem,Jeffers Helen,Jesudason Natasha,Jones Bryony,Jones Kathryn,Jones Elizabeth,Jones Christopher,Jorge Marianna Rocha,Jose Aylin,Joshi Amar,Júnior Eduardo A.M.S.,Kadziola Joanne,Kailath Reshma,Kana Faeeza,Karampatsas Konstantinos,Kasanyinga Mwila,Keen Jade,Kelly Elizabeth J.,Kelly Dearbhla M.,Kelly Debbie,Kelly Sarah,Kerr David,Kfouri Renato de Ávila,Khan Liaquat,Khozoee Baktash,Kidd Sarah,Killen Annabel,Kinch Jasmin,Kinch Patrick,King Lloyd D.W.,King Thomas B.,Kingham Lucy,Klenerman Paul,Knapper Francesca,Knight Julian C.,Knott Daniel,Koleva Stanislava,Lang Matilda,Lang Gail,Larkworthy Colin W.,Larwood Jessica P.J.,Law Rebecca,Lazarus Erica M.,Leach Amanda,Lees Emily A.,Lemm Nana-Marie,Lessa Alvaro,Leung Stephanie,Li Yuanyuan,Lias Amelia M.,Liatsikos Kostas,Linder Aline,Lipworth Samuel,Liu Shuchang,Liu Xinxue,Lloyd Adam,Lloyd Stephanie,Loew Lisa,Lopez Ramon Raquel,Lora Leandro,Lowthorpe Vicki,Luz Kleber,MacDonald Jonathan C.,MacGregor Gordon,Madhavan Meera,Mainwaring David O.,Makambwa Edson,Makinson Rebecca,Malahleha Mookho,Malamatsho Ross,Mallett Garry,Mansatta Kushal,Maoko Takalani,Mapetla Katlego,Marchevsky Natalie G.,Marinou Spyridoula,Marlow Emma,Marques Gabriela N.,Marriott Paula,Marshall Richard P.,Marshall Julia L.,Martins Flávia J.,Masenya Masebole,Masilela Mduduzi,Masters Shauna K.,Mathew Moncy,Matlebjane Hosea,Matshidiso Kedidimetse,Mazur Olga,Mazzella Andrea,McCaughan Hugh,McEwan Joanne,McGlashan Joanna,McInroy Lorna,McIntyre Zoe,McLenaghan Daniela,McRobert Nicky,McSwiggan Steve,Megson Clare,Mehdipour Savviz,Meijs Wilma,Mendonça Renata N.Á.,Mentzer Alexander J.,Mirtorabi Neginsadat,Mitton Celia,Mnyakeni Sibusiso,Moghaddas Fiona,Molapo Kgaogelo,Moloi Mapule,Moore Maria,Moraes-Pinto M. Isabel,Moran Marni,Morey Ella,Morgans Róisín,Morris Susan,Morris Sheila,Morris Helen C.,Morselli Franca,Morshead Gertraud,Morter Richard,Mottal Lynelle,Moultrie Andrew,Moya Nathifa,Mpelembue Mushiya,Msomi Sibekezelo,Mugodi Yvonne,Mukhopadhyay Ekta,Muller Jilly,Munro Alasdair,Munro Claire,Murphy Sarah,Mweu Philomena,Myasaki Celia Hatsuko,Naik Gurudutt,Naker Kush,Nastouli Eleni,Nazir Abida,Ndlovu Bongani,Neffa Fabio,Njenga Cecilia,Noal Helena,Noé Andrés,Novaes Gabrielle,Nugent Fay L.,Nunes Géssika,O'Brien Katie,O'Connor Daniel,Odam Miranda,Oelofse Suzette,Oguti Blanche,Olchawski Victoria,Oldfield Neil J.,Oliveira Marianne G.,Oliveira Catarina,Oosthuizen Angela,O'Reilly Paula,Osborne Piper,Owen David R.J.,Owen Lydia,Owens Daniel,Owino Nelly,Pacurar Mihaela,Paiva Brenda V.B.,Palhares Edna M.F.,Palmer Susan,Parkinson Sivapriyai,Parracho Helena M.R.T.,Parsons Karen,Patel Dipak,Patel Bhumika,Patel Faeezah,Patel Kelly,Patrick-Smith Maia,Payne Ruth O.,Peng Yanchun,Penn Elizabeth J.,Pennington Anna,Peralta Alvarez Marco Polo,Perring James,Perry Nicola,Perumal Rubeshan,Petkar Sahir,Philip Tricia,Phillips Daniel J.,Phillips Jennifer,Phohu Mary Kgomotso,Pickup Lorinda,Pieterse Sonja,Piper Jo,Pipini Dimitra,Plank Mary,Du Plessis Joan,Pollard Samuel,Pooley Jennifer,Pooran Anil,Poulton Ian,Powers Claire,Presa Fernando B.,Price David A.,Price Vivien,Primeira Marcelo,Proud Pamela C.,Provstgaard-Morys Samuel,Pueschel Sophie,Pulido David,Quaid Sheena,Rabara Ria,Radford Alexandra,Radia Kajal,Rajapaska Durga,Rajeswaran Thurkka,Ramos Alberto San Francisco,Ramos Lopez Fernando,Rampling Tommy,Rand Jade,Ratcliffe Helen,Rawlinson Tom,Rea David,Rees Byron,Reiné Jesús,Resuello-Dauti Mila,Reyes Pabon Emilia,Ribiero Carla M.,Ricamara Marivic,Richter Alex,Ritchie Neil,Ritchie Adam J.,Robbins Alexander J.,Roberts Hannah,Robinson Ryan E.,Robinson Hannah,Rocchetti Talita T.,Rocha Beatriz Pinho,Roche Sophie,Rollier Christine,Rose Louisa,Ross Russell Amy L.,Rossouw Lindie,Royal Simon,Rudiansyah Indra,Ruiz Sarah,Saich Stephen,Sala Claudia,Sale Jessica,Salman Ahmed M.,Salvador Natalia,Salvador Stephannie,Sampaio Milla,Samson Annette D.,Sanchez-Gonzalez Amada,Sanders Helen,Sanders Katherine,Santos Erika,Santos Guerra Mayara F.S.,Satti Iman,Saunders Jack E.,Saunders Caroline,Sayed Aakifah,Schim van der Loeff Ina,Schmid Annina B.,Schofield Ella,Screaton Gavin,Seddiqi Samiullah,Segireddy Rameswara R.,Senger Roberta,Serrano Sonia,Shah Rajiv,Shaik Imam,Sharpe Hannah E.,Sharrocks Katherine,Shaw Robert,Shea Adam,Shepherd Amy,Shepherd James G.,Shiham Farah,Sidhom Emad,Silk Sarah E.,da Silva Moraes Antonio Carlos,Silva-Junior Gilberto,Silva-Reyes Laura,Silveira Anderson D.,Silveira Mariana B.V.,Sinha Jaisi,Skelly Donal T.,Smith Daniel C.,Smith Nick,Smith Holly E.,Smith David J.,Smith Catherine C.,Soares Airanuédida,Soares Tiago,Solórzano Carla,Sorio Guilherme L.,Sorley Kim,Sosa-Rodriguez Tiffany,Souza Cinthia M.C.D.L.,Souza Bruno S.D.F.,Souza Alessandra R.,Spencer Alexandra J.,Spina Fernanda,Spoors Louise,Stafford Lizzie,Stamford Imogen,Starinskij Igor,Stein Ricardo,Steven Jill,Stockdale Lisa,Stockwell Lisa V.,Strickland Louise H.,Stuart Arabella C.,Sturdy Ann,Sutton Natalina,Szigeti Anna,Tahiri-Alaoui Abdessamad,Tanner Rachel,Taoushanis Carol,Tarr Alexander W.,Taylor Keja,Taylor Ursula,Taylor Iona Jennifer,Taylor Justin,te Water Naude Rebecca,Themistocleous Yrene,Themistocleous Andreas,Thomas Merin,Thomas Kelly,Thomas Tonia M.,Thombrayil Asha,Thompson Fawziyah,Thompson Amber,Thompson Kevin,Thompson Ameeka,Thomson Julia,Thornton-Jones Viv,Tighe Patrick J.,Tinoco Lygia Accioly,Tiongson Gerlynn,Tladinyane Bonolo,Tomasicchio Michele,Tomic Adriana,Tonks Susan,Towner James,Tran Nguyen,Tree Julia,Trillana Gerry,Trinham Charlotte,Trivett Rose,Truby Adam,Tsheko Betty Lebogang,Turabi Aadil,Turner Richard,Turner Cheryl,Ulaszewska Marta,Underwood Benjamin R.,Varughese Rachel,Verbart Dennis,Verheul Marije,Vichos Iason,Vieira Taiane,Waddington Claire S.,Walker Laura,Wallis Erica,Wand Matthew,Warbick Deborah,Wardell Theresa,Warimwe George,Warren Sarah C.,Watkins Bridget,Watson Ekaterina,Webb Stewart,Webb-Bridges Alice,Webster Angela,Welch Jessica,Wells Jeanette,West Alison,White Caroline,White Rachel,Williams Paul,Williams Rachel L.,Winslow Rebecca,Woodyer Mark,Worth Andrew T.,Wright Danny,Wroblewska Marzena,Yao Andy,Zimmer Rafael,Zizi Dalila,Zuidewind Peter

Publisher

Elsevier BV

Subject

General Medicine

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