Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Author:

Ramasamy Maheshi N,Minassian Angela M,Ewer Katie J,Flaxman Amy L,Folegatti Pedro M,Owens Daniel R,Voysey Merryn,Aley Parvinder K,Angus Brian,Babbage Gavin,Belij-Rammerstorfer Sandra,Berry Lisa,Bibi Sagida,Bittaye Mustapha,Cathie Katrina,Chappell Harry,Charlton Sue,Cicconi Paola,Clutterbuck Elizabeth A,Colin-Jones Rachel,Dold Christina,Emary Katherine R W,Fedosyuk Sofiya,Fuskova Michelle,Gbesemete Diane,Green Catherine,Hallis Bassam,Hou Mimi M,Jenkin Daniel,Joe Carina C D,Kelly Elizabeth J,Kerridge Simon,Lawrie Alison M,Lelliott Alice,Lwin May N,Makinson Rebecca,Marchevsky Natalie G,Mujadidi Yama,Munro Alasdair P S,Pacurar Mihaela,Plested Emma,Rand Jade,Rawlinson Thomas,Rhead Sarah,Robinson Hannah,Ritchie Adam J,Ross-Russell Amy L,Saich Stephen,Singh Nisha,Smith Catherine C,Snape Matthew D,Song Rinn,Tarrant Richard,Themistocleous Yrene,Thomas Kelly M,Villafana Tonya L,Warren Sarah C,Watson Marion E E,Douglas Alexander D,Hill Adrian V S,Lambe Teresa,Gilbert Sarah C,Faust Saul N,Pollard Andrew J,Aboagye Jeremy,Adams Kelly,Ali Aabidah,Allen Elizabeth R.,Allen Lauren,Allison Jennifer L.,Andritsou Foteini,Anslow Rachel,Arbe-Barnes Edward H.,Baker Megan,Baker Natalie,Baker Philip,Baleanu Ioana,Barker Debbie,Barnes Eleanor,Barrett Jordan R.,Barrett Kelly,Bates Louise,Batten Alexander,Beadon Kirsten,Beckley Rebecca,Bellamy Duncan,Berg Adam,Bermejo Laura,Berrie Eleanor,Beveridge Amy,Bewley Kevin,Bijker Else M.,Birch Geeta,Blackwell Luke,Bletchly Heather,Blundell Caitlin L.,Blundell Susannah R.,Bolam Emma,Boland Elena,Bormans Daan,Borthwick Nicola,Boukas Konstantinos,Bower Thomas,Bowring Francesca,Boyd Amy,Brenner Tanja,Brown Phillip,Brown-O'Sullivan Charlie,Bruce Scott,Brunt Emily,Burbage Jamie,Burgoyne Joshua,Buttigieg Karen R.,Byard Nicholas,Cabera Puig Ingrid,Camara Susana,Cao Michelangelo,Cappuccini Federica,Carr Melanie,Carroll Miles W.,Cashen Paul,Cavey Ana,Chadwick Jim,Challis Ruth,Chapman David,Charles David,Chelysheva Irina,Cho Jee-Sun,Cifuentes Liliana,Clark Elizabeth,Collins Sarah,Conlon Christopher P.,Coombes Naomi S.,Cooper Rachel,Cooper Cushla,Crocker Wendy E.M.,Crosbie Sarah,Cullen Dan,Cunningham Christina,Cuthbertson Fiona,Datoo Brad E.,Dando Lynne,Datoo Mehreen S.,Datta Chandrabali,Davies Hannah,Davies Sarah,Davis Elizabeth J.,Davis Judith,Dearlove David,Demissie Tesfaye,Di Marco Stefania,Di Maso Claudio,DiTirro Danielle,Docksey Claire,Dong Tao,Donnellan Francesca R.,Douglas Naomi,Downing Charlotte,Drake Jonathan,Drake-Brockman Rachael,Drury Ruth E.,Dunachie Susanna J.,Edwards Christopher J.,Edwards Nick J.,El Muhanna Omar,Elias Sean C.,Elliott Ryan S.,Elmore Michael J.,English Marcus Rex,Felle Sally,Feng Shuo,Ferreira Da Silva Carla,Field Samantha,Fisher Richard,Fixmer Carine,Ford Karen J.,Fowler Jamie,Francis Emma,Frater John,Furze Julie,Galian-Rubio Pablo,Galloway Celine,Garlant Harriet,Gavrila Madita,Gibbons Felicity,Gibbons Karyna,Gilbride Ciaran,Gill Hardeep,Godwin Kerry,Gordon-Quayle Katherine,Gorini Giacomo,Goulston Lyndsey,Grabau Caroline,Gracie Lara,Graham Nichola,Greenwood Nicola,Griffiths Oliver,Gupta Gaurav,Hamilton Elizabeth,Hanumunthadu Brama,Harris Stephanie A.,Harris Tara,Harrison Daisy,Hart Thomas C.,Hartnell Birgit,Haskell Louise,Hawkins Sophia,Henry John Aaron,Hermosin Herrera Macarena,Hill David,Hill Jennifer,Hodges Gina,Hodgson Susanne H.C.,Horton Katie L.,Howe Elizabeth,Howell Nicola,Howes Jessica,Huang Ben,Humphreys Jonathan,Humphries Holly E.,Iveson Poppy,Jackson Frederic,Jackson Susan,Jauregui Sam,Jeffers Helen,Jones Bryony,Jones Christine E.,Jones Elizabeth,Jones Kathryn,Joshi Amar,Kailath Reshma,Keen Jade,Kelly Dearbhla M.,Kelly Sarah,Kelly Debbie,Kerr David,Khan Liaquat,Khozoee Baktash,Killen Annabel,Kinch Jasmin,King Lloyd D.W.,King Thomas B.,Kingham Lucy,Klenerman Paul,Knight Julian C.,Knott Daniel,Koleva Stanislava,Lang Gail,Larkworthy Colin W.,Larwood Jessica P.J.,Law Rebecca,Lee Arlene,Lee Kim Y.N.,Lees Emily A.,Leung Stephanie,Li Yuanyuan,Lias Amelia M.,Linder Aline,Lipworth Samuel,Liu Shuchang,Liu Xinxue,Lloyd Stephanie,Loew Lisa,Lopez Ramon Raquel,Madhavan Meera,Mainwaring David O.,Mallett Garry,Mansatta Kushal,Marinou Spyridoula,Marius Phedra,Marlow Emma,Marriott Paula,Marshall Julia L.,Martin Jane,Masters Shauna,McEwan Joanne,McGlashan Joanna L.,McInroy Lorna,McRobert Nicky,Megson Clare,Mentzer Alexander J.,Mirtorabi Neginsadat,Mitton Celia,Moore Maria,Moran Marni,Morey Ella,Morgans Róisín,Morris Susan J.,Morrison Hazel Morrison,Morshead Gertraud,Morter Richard,Moya Nathifa A.,Mukhopadhyay Ekta,Muller Jilly,Munro Claire,Murphy Sarah,Mweu Philomena,Noé Andrés,Nugent Fay L.,O'Brien Katie,O'Connor Daniel,Oguti Blanché,Olchawski Victoria,Oliveira Catarina,O'Reilly Peter John,Osborne Piper,Owen Lydia,Owino Nelly,Papageorgiou Panagiotis,Parracho Helena,Parsons Karen,Patel Bhumika,Patrick-Smith Maia,Peng Yanchun,Penn Elizabeth J.,Peralta-Alvarez Marco Polo,Perring James,Petropoulos Christos,Phillips Daniel J.,Pipini Dimitra,Pollard Samuel,Poulton Ian,Pratt Danny,Presland Laura,Proud Pamela C.,Provstgaard-Morys Samuel,Pueschel Sophie,Pulido David,Rabara Ria,Radia Kajal,Rajapaska Durga,Ramos Lopez Fernando,Ratcliffe Helen,Rayhan Sara,Rees Byron,Reyes Pabon Emilia,Roberts Hannah,Robertson Isla,Roche Sophie,Rollier Christine S.,Romani Rossana,Rose Zoe,Rudiansyah Indra,Sabheha Sabeha,Salvador Stephannie,Sanders Helen,Sanders Katherine,Satti Iman,Sayce Chloe,Schmid Annina B.,Schofield Ella,Screaton Gavin,Sedik Cynthia,Seddiqi Samiullah,Segireddy Rameswara R.,Selby Beatrice,Shaik Imam,Sharpe Hannah R.,Shaw Robert,Shea Adam,Silk Sarah,Silva-Reyes Laura,Skelly Donal T.,Smith David J.,Smith Daniel C.,Smith Nicholas,Spencer Alexandra J.,Spoors Louise,Stafford Elizabeth,Stamford Imogen,Stockdale Lisa,Stockley David,Stockwell Lisa V.,Stokes Matthew,Strickland Louise H.,Stuart Arabella,Sulaiman Sulaiman,Summerton Eloise,Swash Zoe,Szigeti Anna,Tahiri-Alaoui Abdessamad,Tanner Rachel,Taylor Iona,Taylor Keja,Taylor Ursula,te Water Naude Rebecca,Themistocleous Andreas,Thomas Merin,Thomas Tonia M.,Thompson Amber,Thompson Kevin,Thornton-Jones Viv,Tinh Lan,Tomic Adriana,Tonks Susan,Towner James,Tran Nguyen,Tree Julian A.,Truby Adam,Turner Cheryl,Turner Richard,Ulaszewska Marta,Varughese Rachel,Verbart Dennis,Verheul Marije K.,Vichos Iason,Walker Laura,Wand Matthew E.,Watkins Bridget,Welch Jessica,West Alison J.,White Caroline,White Rachel,Williams Paul,Woodyer Mark,Worth Andrew T.,Wright Daniel,Wrin Terri,Yao Xin Li,Zbarcea Diana-Andreea,Zizi Dalila

Funder

National Institute for Health Research

Coalition for Epidemic Preparedness Innovations

UK Research and Innovation

Publisher

Elsevier BV

Subject

General Medicine

Reference27 articles.

1. Coronavirus disease (COVID-19) dashboard,2020

2. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases From the Chinese Center for Disease Control and Prevention;Wu;JAMA,2020

3. Draft landscape of COVID-19 vaccine candidates,2020

4. WHO target product profiles for COVID-19 vaccines: version 3,2020

5. Immunosenescence: emerging challenges for an ageing population;Aw;Immunology,2007

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