Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor-Reference-Cited by-同舟云学术

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Published:2021-06-03 Issue:12 Volume:64 Page:8076-8100
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McKinzie David L.¹,Winneroski Leonard L.¹,Green Steven J.¹,Hembre Erik J.¹,Erickson Jon A.¹,Willis Brian A.¹,Monk Scott A.¹,Aluise Christopher D.¹,Baker Thomas K.¹,Lopez Jose E.¹,Hendle Jörg²,Beck James P.²,Brier Richard A.¹,Boggs Leonard N.,Borders Anthony R.¹,Cocke Patrick J.,Garcia-Losada Pablo¹,Lowe Stephen L.¹,Mathes Brian M.¹,May Patrick C.,Porter Warren J.,Stout Stephanie L.¹,Timm David E.¹,Watson Brian M.¹,Yang Zhixiang¹,Mergott Dustin J.¹^ORCID

Affiliation:

1. Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States

2. Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California 92121, United States

Funder

Eli Lilly and Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00489

Reference52 articles.

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2. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

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4. The secretases: enzymes with therapeutic potential in Alzheimer disease

5. New evolutions in the BACE1 inhibitor field from 2014 to 2018

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