Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y<sub>14</sub>R Antagonist-Reference-Cited by-同舟云学术

Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y₁₄R Antagonist

Published:2022-02-03 Issue:4 Volume:65 Page:3434-3459
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wen Zhiwei¹^ORCID,Salmaso Veronica¹,Jung Young-Hwan¹,Phung Ngan B.¹,Gopinatth Varun¹,Shah Qasim¹,Patterson Alexandra T.¹^ORCID,Randle John C. R.²,Chen Zhoumou³,Salvemini Daniela³,Lieberman David I.¹,Whitehead Gregory S.⁴,Karcz Tadeusz P.⁴^ORCID,Cook Donald N.⁴,Jacobson Kenneth A.¹^ORCID

Affiliation:

1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States

2. Random Walk Ventures, LLC, 108 Lincoln Street Unit 6B, Boston, Massachusetts 02111, United States

3. Department of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, Missouri 63104, United States

4. Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States

Funder

National Institute of Environmental Health Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01964

Reference77 articles.

1. UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation

2. A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose–Stimulated Chemotaxis of Human Neutrophils