Discovery of N-Substituted Acetamide Derivatives as Promising P2Y<sub>14</sub>R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay-Reference-Cited by-同舟云学术

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Discovery of N-Substituted Acetamide Derivatives as Promising P2Y₁₄R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay

Published:2024-06-14 Issue:12 Volume:67 Page:10233-10247
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Wenjin¹²,Mao Shuqiang³,Wang Yuyang¹,Wang Mingzhu¹,Li Mengyu²,Sun Moran²,Yao Yongfang²⁴^ORCID,Song Chuanjun³⁴^ORCID,Duan Yongtao¹

Affiliation:

1. Henan Provincial Key Laboratory of Pediatric Hematology, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China

2. School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China

3. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

4. Pingyuan Laboratory, Zhengzhou University, Zhengzhou 450001, China

Funder

Natural Science Foundation of Henan Province

Joint Fund of Henan Provincial Science and Technology Research

Henan Medical Science and Technology Program

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00555

Reference32 articles.

1. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors

2. The inflammatory role of silent urate crystal deposition in intercritical gout

3. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

4. Update of P2Y receptor pharmacology: IUPHAR Review 27

5. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

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