A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose–Stimulated Chemotaxis of Human Neutrophils

Author:

Barrett Matthew O.,Sesma Juliana I.,Ball Christopher B.,Jayasekara P. Suresh,Jacobson Kenneth A.,Lazarowski Eduardo R.,Harden T. Kendall

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference43 articles.

1. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

2. The UDP-Glucose Receptor P2RY14 Triggers Innate Mucosal Immunity in the Female Reproductive Tract by Inducing IL-8

3. Belly M, Deschenes D, Fortin R, Fournier JF, Gagne S, Gareau Y, Gautheir JY, Li L, Robichaud J, Therien M, Tranmer GK, and Wang Z (2009) inventors, Merck Frosst Canada LTD, assignee. Substituted 2-naphthoic acids as antagonists of GPR105 activity. WO 2009/070873A1. 2010 Nov 25.

4. Synthesis, Chemical Properties, and Preliminary Evaluation of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one Alkylation Subunit:  Hammett Quantitation of the Magnitude of Electronic Effects on Functional Reactivity

5. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells;Brown;Mol Pharmacol,1991

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