First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

Author:

Nowak Radosław P.1ORCID,Tumber Anthony12,Hendrix Eline3,Ansari Mohammad Salik Zeya4,Sabatino Manuela5,Antonini Lorenzo5,Andrijes Regina3,Salah Eidarus2,Mautone Nicola6,Pellegrini Francesca Romana4,Simelis Klemensas2,Kawamura Akane7ORCID,Johansson Catrine12,Passeri Daniela8,Pellicciari Roberto8,Ciogli Alessia6,Del Bufalo Donatella9,Ragno Rino5ORCID,Coleman Mathew L.3,Trisciuoglio Daniela4,Mai Antonello6ORCID,Oppermann Udo1ORCID,Schofield Christopher J.2ORCID,Rotili Dante6ORCID

Affiliation:

1. Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington OX3 7LD, U.K.

2. Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12, Mansfield Road, University of Oxford, Oxford OX1 3TA, U.K.

3. Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.

4. Institute of Molecular Biology and Pathology (IMBP), National Research Council (CNR) c/o Department of Biology and Biotechnology “Charles Darwin” Sapienza University of Rome, Via degli Apuli 4, Rome 00185, Italy

5. Rome Center for Molecular Design, Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy

6. Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy

7. Chemistry - School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.

8. TES Pharma S.r.l. Via P. Togliatti 20, Corciano, Perugia 06073, Italy

9. Preclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy

Funder

Regione Lazio

Arthritis Research UK

Ministero dell???Istruzione, dell???Universit?? e della Ricerca

Sapienza Universit?? di Roma

Associazione Italiana per la Ricerca sul Cancro

Wellcome Trust

Cancer Research UK

Leducq Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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