First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

Author:

Fiorentino Francesco1ORCID,Sementilli Sara2,Menna Martina1,Turrisi Federica2,Tomassi Stefano3ORCID,Pellegrini Francesca Romana2,Iuzzolino Angela2,D’Acunzo Francesca4,Feoli Alessandra5ORCID,Wapenaar Hannah6,Taraglio Sophie7,Fraschetti Caterina1ORCID,Del Bufalo Donatella8,Sbardella Gianluca5ORCID,Dekker Frank J.6ORCID,Paiardini Alessandro7,Trisciuoglio Daniela2,Mai Antonello19ORCID,Rotili Dante1ORCID

Affiliation:

1. Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy

2. Institute of Molecular Biology and Pathology, National Research Council (CNR), Via degli Apuli 4, Rome 00185, Italy

3. Department of Pharmacy, University of Naples “Federico II”, via Domenico Montesano 49, Naples 80131, Italy

4. Institute of Biological Systems (ISB), Italian National Research Council (CNR), Sezione Meccanismi di Reazione, c/o Department of Chemistry, Sapienza University of Rome, P. le A. Moro 5, Rome 00185, Italy

5. Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, Fisciano (SA) 84084, Italy

6. Department of Chemical and Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands

7. Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy

8. Preclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy

9. Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy

Funder

Regione Lazio

Sapienza Universit? di Roma

Associazione Italiana per la Ricerca sul Cancro

Universit? degli Studi di Salerno

Banca d'Italia

Ministero dell'Universit? e della Ricerca

Regione Campania

Central European Research Infrastructure Consortium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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