Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease

Published:2021-10-14 Issue:20 Volume:64 Page:15262-15279
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Machauer Rainer¹^ORCID,Lueoend Rainer¹,Hurth Konstanze¹,Veenstra Siem J.¹,Rueeger Heinrich¹,Voegtle Markus¹,Tintelnot-Blomley Marina¹,Rondeau Jean-Michel²,Jacobson Laura H.³,Laue Grit⁴,Beltz Karen⁴,Neumann Ulf³

Affiliation:

1. Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland

2. Chemical Biology and Therapeutics, Structural Biology Platform, Novartis Pharma AG, CH-4056 Basel, Switzerland

3. Department of Neuroscience, Novartis Pharma AG, CH-4056 Basel, Switzerland

4. Pharmacokinetic-Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01300

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