Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis-Reference-Cited by-同舟云学术

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Published:2022-03-18 Issue:7 Volume:65 Page:5606-5624
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Smith Alasdair¹,Wall Richard J.²,Patterson Stephen²,Rowan Tim³,Rico Vidal Eva²,Stojanovski Laste¹,Huggett Margaret¹,Hampton Shahienaz E.¹^ORCID,Thomas Michael G.¹^ORCID,Corpas Lopez Victoriano²,Gillingwater Kirsten⁴⁵,Duke Jeff⁶,Napier Grant³,Peter Rose³,Vitouley Hervé S.⁷,Harrison Justin R.¹,Milne Rachel²,Jeacock Laura²,Baker Nicola²,Davis Susan H.¹,Simeons Frederick¹,Riley Jennifer¹,Horn David²,Brun Reto⁴⁵,Zuccotto Fabio¹^ORCID,Witty Michael J³,Wyllie Susan²^ORCID,Read Kevin D.¹^ORCID,Gilbert Ian H.¹^ORCID

Affiliation:

1. Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom

2. Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom

3. GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom

4. Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland

5. University of Basel, Petersplatz 1, CH-4001 Basel, Switzerland

6. University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB United Kingdom

7. Centre International de Recherche-Développement sur l’Elevage en zone Subhumide (CIRDES), No 559 ru 5-31 angle Av. du Gouverneur Louveau, 01 BP: 454 Bobo-Dioulasso 01, Burkina Faso

Funder

Bill and Melinda Gates Foundation

Wellcome Trust

UK Government

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02104

Reference22 articles.

1. African bovine trypanosomiasis: the problem of drug resistance