Sperm Toolbox – A selection of small molecules to study human spermatozoa-Reference-Cited by-同舟云学术

Sperm Toolbox – A selection of small molecules to study human spermatozoa

Published:2023-05-02 Issue: Volume: Page:
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Author:

Gruber Franz S.^ORCID,Richardson Anthony^ORCID,Johnston Zoe C.^ORCID,Myles Rachel^ORCID,Norcross Neil^ORCID,Day David,Georgiou Irene^ORCID,Sanz Laura Sesma^ORCID,Wilson Caroline^ORCID,Read Kevin D.^ORCID,da Silva Sarah Martins^ORCID,Barratt Christopher L. R.^ORCID,Gilbert Ian H.^ORCID,Swedlow Jason R.^ORCID

Abstract

AbstractMale contraceptive options and infertility treatments are limited. To help overcome these limitations we established a small molecule library as a toolbox for assay development and screening campaigns using human spermatozoa. We have profiled all compounds in our automated high-throughput screening platform and provide the dataset, which allows direct side-by-side comparisons of compound effects and assays using live human spermatozoa.

Publisher

Cold Spring Harbor Laboratory

Reference22 articles.

1. Male contraceptive development: A medicinal chemistry perspective

2. A brief history and future prospects of contraception

3. Emerging concepts in male contraception: a narrative review of novel, hormonal and non-hormonal options

4. On-demand male contraception via acute inhibition of soluble adenylyl cyclase

5. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice

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