Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors-Reference-Cited by-同舟云学术

Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors

Published:2022-02-16 Issue:5 Volume:65 Page:4121-4155
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hartz Richard A.¹^ORCID,Ahuja Vijay T.¹,Nara Susheel J.²^ORCID,Kumar C. M. Vijaya²,Manepalli Raju K. V. L. P.²,Sarvasiddhi Sarat Kumar²,Honkhambe Swarnamba²,Patankar Vidya²,Dasgupta Bireshwar¹,Rajamani Ramkumar³,Muckelbauer Jodi K.⁴,Camac Daniel M.⁴,Ghosh Kaushik²^ORCID,Pokross Matthew⁴,Kiefer Susan E.⁵,Brown Jeffrey M.⁶,Hunihan Lisa⁶,Gulianello Michael⁶,Lewis Martin⁶,Lippy Jonathan S.⁷,Surti Neha⁷,Hamman Brian D.⁸,Allen Jason⁸,Kostich Walter A.⁶,Bronson Joanne J.¹,Macor John E.¹,Dzierba Carolyn D.¹

Affiliation:

1. Department of Small Molecule Drug Discovery, Bristol Myers Squibb Company, Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore 560099, India

3. Department of Molecular Structure and Design, Bristol Myers Squibb Company, Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

4. Department of Molecular Structure and Design, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

5. Department of Protein Science, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

6. Department of Neuroscience Discovery Biology, Bristol Myers Squibb Company, Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

7. Department of Lead Evaluation, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

8. Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, Texas 77381, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01966

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