Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain-Reference-Cited by-同舟云学术

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain

Published:2023-06-03 Issue:7 Volume:32 Page:1369-1375
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Dzierba Carolyn D.^ORCID,Dasgupta Bireshwar,Karageorge George,Kostich Walter,Hamman Brian,Allen Jason,Esposito Kim M.,Padmanabha Ramesh,Grace James,Lentz Kimberley,Morrison John,Morgan Daniel,Easton Amy,Bourin Clotilde,Browning Marc R.,Rajamani Ramkumar,Good Andrew,Parker Dawn D.,Muckelbauer Jodi K.,Khan Javed,Camac Daniel,Ghosh Kaushik,Halan Vivek,Lippy Jonathan S.,Santone Kenneth S.,Denton R. Rex,Westphal Ryan,Bristow Linda J.,Conway Charles M.,Bronson Joanne J.,Macor John E.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-023-03079-x.pdf

Reference29 articles.

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2. Sorrell FJ, Szklarz M, Abdul Azeez KR, Elkins JM, Knapp S. Family-wide structural analysis of human Numb-associated protein kinases. Structure. 2016;24:401–11. https://doi.org/10.1016/j.str.2015.12.015.

3. Sorensen EB, Conner SD. AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis. Traffic. 2008;9:1791–800. https://doi.org/10.1111/j.1600-0854.2008.00790.x.

4. Gupta-Rossi N, Ortica S, Meas-Yedid V, Heuss S, Moretti J, Olivo-Marin JC, et al. The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. J Biol Chem. 2011;286:18720–30. https://doi.org/10.1074/jbc.M110.190769.

5. Abdel-Magid A. F. Inhibitors of Adaptor-Associated Kinase 1 (AAK1) May Treat Neuropathic Pain, Schizophrenia, Parkinson’s Disease, and Other Disorders. ACS Med Chem Lett. 2017;8:595–7. https://doi.org/10.1021/acsmedchemlett.7b00208.