Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach-Reference-Cited by-同舟云学术

Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach

Published:2021-06-10 Issue:12 Volume:64 Page:8710-8726
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mallo-Abreu Ana¹²,Reyes-Resina Irene³⁴,Azuaje Jhonny¹²,Franco Rafael⁵⁴^ORCID,García-Rey Aitor¹²,Majellaro Maria¹²,Miranda-Pastoriza Darío¹²,García-Mera Xerardo²,Jespers Willem⁶^ORCID,Gutiérrez-de-Terán Hugo⁶^ORCID,Navarro Gemma³⁴,Sotelo Eddy¹²^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

2. Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

3. Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain

4. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain

5. Faculty of Chemistry, University of Barcelona, 08028 Barcelona, Spain

6. Department of Cell and Molecular Biology, Uppsala University, Uppsala SE-75124, Sweden

Funder

Vetenskapsr??det

Forskningsr??det om H??lsa, Arbetsliv och V??lf??rd

European Regional Development Fund

Ministerio de Econom??a y Competitividad

Conseller??a de Cultura, Educaci??n e Ordenaci??n Universitaria, Xunta de Galicia

Deputaci??n Provincial da Coru??a

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00704

Reference69 articles.

1. Structural diversity of G protein-coupled receptors and significance for drug discovery

2. A comprehensive map of molecular drug targets

3. Biased signalling: from simple switches to allosteric microprocessors

4. Functional Selectivity and Classical Concepts of Quantitative Pharmacology

5. β-arrestin-mediated receptor trafficking and signal transduction

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