Biased signalling: from simple switches to allosteric microprocessors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd.2017.229.pdf
Reference223 articles.
1. Lagerstrom, M. C. & Schioth, H. B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov. 7, 339–357 (2008).
2. Luttrell, L. M., Maudsley, S. & Bohn, L. M. Fulfilling the promise of “biased” G protein-coupled receptor agonism. Mol. Pharmacol. 88, 579–588 (2015).
3. Santos, R. et al. A comprehensive map of molecular drug targets. Nat. Rev. Drug Discov. 16, 19–34 (2017).
4. Smith, J. S. & Rajagopal, S. The β-arrestins: multifunctional regulators of G protein-coupled receptors. J. Biol Chem. 291, 8969–8977 (2016).
5. Benovic, J. L., Strasser, R. H., Caron, M. G. & Lefkowitz, R. J. β-Adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc. Natl Acad. Sci. USA 83, 2797–2801 (1986).
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