Discovery of 3,5-Dimethyl-4-Sulfonyl-1H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability-Reference-Cited by-同舟云学术

Discovery of 3,5-Dimethyl-4-Sulfonyl-1H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability

Published:2021-08-03 Issue:15 Volume:64 Page:11330-11353
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhu Peng-Ju¹²,Yu Ze-Zhou¹²,Lv Yi-Fei¹²,Zhao Jing-Long¹²,Tong Yuan-Yuan¹²,You Qi-Dong¹²^ORCID,Jiang Zheng-Yu¹²^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Funder

China Association for Science and Technology

Jiangsu Provincial Department of Education

China Pharmaceutical University

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00682

Reference79 articles.

1. Mitochondria and Apoptosis

2. The Bcl-2 Protein Family: Arbiters of Cell Survival

3. Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins

4. BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

5. The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

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