Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1<i>H</i>-indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells-Reference-Cited by-同舟云学术

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Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1H-indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells

Published:2024-08-09 Issue:16 Volume:67 Page:13925-13958
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Deng Hongguang¹,Zhang Jingyi²,Liu Liang¹,Zhang Hong¹,Han Yu¹,Wu Linlin²,Jing Yongkui²^ORCID,Huang Min¹,Zhao Linxiang¹^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

2. Liaoning Key Laboratory of Targeting Drugs for Hematological Malignancies, Shenyang Pharmaceutical University, Shenyang 110016, China

Funder

Liaoning Revitalization Talents Program

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00643

Reference49 articles.

1. Hallmarks of Cancer: The Next Generation

2. Hallmarks of Cancer: New Dimensions

3. The BCL-2 protein family: opposing activities that mediate cell death

4. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

5. Mechanisms of BCL-2 family proteins in mitochondrial apoptosis

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