Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme-Reference-Cited by-同舟云学术

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Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme

Published:2024-08-13 Issue:17 Volume:67 Page:15691-15710
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Zekun¹²,Guo Mochen¹²,Gu Mingxiao¹²,Cai Zhongtian¹²,Wu Qiuyu¹²,Yu Jia¹²,Tang Meilun¹²,He Chenxi¹²,Wang Yuxuan¹²,Sun Piaoyang³,You Qidong¹²^ORCID,Wang Lei¹²^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

3. Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai 200245, China

Funder

China Association for Science and Technology

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01304

Reference63 articles.

1. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

2. Druggable cancer phosphatases

3. Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer

4. Targeting phosphatases: From molecule design to clinical trials

5. Approaches to Study Phosphatases

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