Brain-Penetrant Macrocycles: Design Considerations, Future Prospects, and Call for Papers-Reference-Cited by-同舟云学术

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Brain-Penetrant Macrocycles: Design Considerations, Future Prospects, and Call for Papers

Published:2024-05-07 Issue:10 Volume:67 Page:7665-7667
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Malinky Cori A.¹,Bender Aaron M.²^ORCID

Affiliation:

1. University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States

2. Vanderbilt Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 393 Nichol Mill Ln., Franklin, Tennessee 37067, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00968

Reference7 articles.

1. Macrocycles in Drug Discovery─Learning from the Past for the Future

2. Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model

3. Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

4. Evaluation of the absolute oral bioavailability of the anaplastic lymphoma kinase/c-ROS oncogene 1 kinase inhibitor lorlatinib in healthy participants

5. Demystifying Brain Penetration in Central Nervous System Drug Discovery

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