Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP-Reference-Cited by-同舟云学术

Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP

Published:2023-06-02 Issue:12 Volume:66 Page:8086-8102
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Feng Zongbo¹²,Yang Chunju¹,Zhang Yi¹,Li Huaxuan¹³,Fang Wei¹,Wang Junhua⁴,Nie Yichu⁵,Wang Chang-Yun³^ORCID,Liu Zhiqing³^ORCID,Jiang Zhimin²,Wang Junjian¹,Wang Yuanxiang¹^ORCID

Affiliation:

1. Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

2. School of Pharmacy, Guilin Medical University, Zhiyuan Road, Lingui District, Guilin 541199, China

3. School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China

4. The Department of Biliary-Pancreatic Surgery, The First People’s Hospital of Foshan, Foshan 528000, China

5. Clinical Research Institute, The First People’s Hospital of Foshan, Foshan 528000, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Guangzhou Basic and Applied Basic Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00411