Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)-Reference-Cited by-同舟云学术

Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)

Published:2023-09-01 Issue:17 Volume:66 Page:12544-12558
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hobson Adrian D.¹^ORCID,Xu Jianwen¹^ORCID,Welch Dennie S.²,Marvin Christopher C.³^ORCID,McPherson Michael J.¹,Gates Bradley²,Liao Xiaoli²,Hollmann Markus⁴^ORCID,Gattner Michael J.⁴,Dzeyk Kristina⁴,Sarvaiya Hetal⁵,Shenoy Vikram M.⁵^ORCID,Fettis Margaret M.¹,Bischoff Agnieszka K.¹,Wang Lu¹,Santora Ling C.¹,Wang Lu¹^ORCID,Fitzgibbons Julia¹^ORCID,Salomon Paulin¹,Hernandez Axel¹,Jia Ying¹,Goess Christian A.¹,Mathieu Suzanne L.¹,Bryant Shaughn H.¹,Larsen Mary E.¹,Cui Baoliang¹,Tian Yu¹

Affiliation:

1. AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States

2. AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

3. AbbVie Inc., 1400 Sheridan Road, North Chicago, Illinois 60064, United States

4. AbbVie Deutschland GmbH & Co KG, Knollstrasse 50, 67061 Ludwigshafen, Germany

5. AbbVie Inc., 1000 Gateway Blvd, South San Francisco, California 94080, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01174

Reference34 articles.

1. An overview of targeted cancer therapy

2. Antibody drug conjugate: the “biological missile” for targeted cancer therapy

3. An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

4. Pushing the Envelope: Advancement of ADCs Outside of Oncology

5. Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery and Evaluation of TLR-Targeted Immune Agonists;Journal of Medicinal Chemistry;2024-09-05

2. Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker;Organic Process Research & Development;2024-06-28

3. Development and Execution of a Scalable Route to an Immunology ADC Drug-Linker for ABBV-154;Organic Process Research & Development;2024-06-25

4. Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model;Journal of Medicinal Chemistry;2024-05-23

5. Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties;RSC Medicinal Chemistry;2024