Development and Execution of a Scalable Route to an Immunology ADC Drug-Linker for ABBV-154-Reference-Cited by-同舟云学术

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Development and Execution of a Scalable Route to an Immunology ADC Drug-Linker for ABBV-154

Published:2024-06-25 Issue:7 Volume:28 Page:2499-2517
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Bennett Nathan B.¹^ORCID,Shen Xiaoqiang¹^ORCID,Gates Bradley D.¹,Welch Dennie S.¹,Servos Mark A.¹,Simanis Justin A.¹,Ellis Ryan G.¹,Qiu Haixiao²,Moschetta Eric G.¹^ORCID,Feng Jiajie³,Boukerche Moussa⁴,Rasmussen Michael¹,McKee Laura A.⁵,Mlinar Laurie B.¹,Chen Shuang¹^ORCID,Wang Zhe¹

Affiliation:

1. Small Molecule CMC Development, AbbVie Inc., North Chicago, Illinois 60064, United States

2. Analytical Development for Synthetics-China, Therapeutics Development & Supply, DPDS, J&J Innovative Medicine R&D, Shanghai 200233, China

3. LyncBio Therapeutics Co., Ltd., Shanghai 201203, China

4. InCryst Ltd., Discovery Park, Sandwich, Kent CT13 9FF, United Kingdom

5. North Chicago Manufacturing, AbbVie Inc., North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00142

Reference48 articles.

1. Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)

2. Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads

3. Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing

4. Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate

5. Development of a Scalable Synthesis of a Drug-Linker for ABBV-3373

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker;Organic Process Research & Development;2024-06-28

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