Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection-Reference-Cited by-同舟云学术

Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection

Published:2023-03-10 Issue:6 Volume:66 Page:4253-4270
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Weixing¹,Guo Lei¹,Liu Haixia¹,Wu Guolong¹,Shi Houguang¹,Zhou Mingwei¹,Zhang Zhisen¹,Kou Buyu¹,Hu Taishan¹,Zhou Zheng²,Xu Zhiheng²,Zhou Xue³,Zhou Yuan³,Tian Xiaojun³,Yang Guang³,Young John A. T.⁴,Qiu Hongxia⁵,Ottaviani Giorgio⁵,Xie Jianxun⁵,Mayweg Alexander V.⁶,Shen Hong C.¹^ORCID,Zhu Wei¹^ORCID

Affiliation:

1. China Innovation Center of Roche, Medicinal Chemistry, Building 5, 371 Lishizhen Road, Shanghai 201203, China

2. China Innovation Center of Roche, Lead Discovery, Building 5, 371 Lishizhen Road, Shanghai 201203, China

3. China Innovation Center of Roche, Discovery Virology, Building 5, 371 Lishizhen Road, Shanghai 201203, China

4. Roche Innovation Center Basel, Discovery Virology, Grenzacherstrasse 124, 4070 Basel, Switzerland

5. China Innovation Center of Roche, Pharmaceutical Sciences, Building 5, 371 Lishizhen Road, Shanghai 201203, China

6. Roche Innovation Center Basel, Medicinal Chemistry, Grenzacherstrasse 124, 4070 Basel, Switzerland

Funder

Roche

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00173

Reference25 articles.

1. World Health Organization (WHO) Fact Sheet N°204, http://www.who.int/mediacentre/factsheets/fs204/en/ (accessed Jan 18, 2023).

2. EASL Clinical Practice Guidelines: Management of chronic hepatitis B

3. EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

4. Novel Therapeutics in Discovery and Development for Treatment of Chronic HBV Infection

5. Novel targets for hepatitis B virus therapy

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