A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for <i>In Vivo</i> Studies-Reference-Cited by-同舟云学术

A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies

Published:2024-07-09 Issue:8 Volume:7 Page:2424-2438
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Chicca Andrea¹,Bátora Daniel¹²,Ullmer Christoph³,Caruso Antonello³^ORCID,Grüner Sabine³,Fingerle Jürgen³,Hartung Thomas³,Degen Roland³,Müller Matthias³,Grether Uwe³^ORCID,Pacher Pal⁴,Gertsch Jürg¹^ORCID

Affiliation:

1. Institute of Biochemistry and Molecular Medicine, University of Bern, Bern 3012, Switzerland

2. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern 3012, Switzerland

3. Pharmaceutical Sciences, Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel 4070, Switzerland

4. Laboratory of Cardiovascular Physiology and Tissue Injury (P.P.), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health (NIH), Bethesda MD 20892-9304, United States

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

National Institute on Alcohol Abuse and Alcoholism

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.4c00269

Reference72 articles.

1. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

2. Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

3. An overview of the cannabinoid type 2 receptor system and its therapeutic potential

4. CB2 Cannabinoid Receptors as a Therapeutic Target—What Does the Future Hold?

5. Targeting cannabinoid receptor CB2 in cardiovascular disorders: promises and controversies

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