4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1<i>H</i>-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells-Reference-Cited by-同舟云学术

4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

Published:2023-10-30 Issue:21 Volume:66 Page:14824-14842
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Masci Domiziana¹,Puxeddu Michela²,Di Magno Laura³,D’Ambrosio Michele²,Parisi Anastasia²,Nalli Marianna²,Bai Ruoli⁴,Coluccia Antonio²^ORCID,Sciò Pietro²,Orlando Viviana⁵,D’Angelo Sara⁵,Biagioni Stefano⁵,Urbani Andrea¹,Hamel Ernest⁴,Nocentini Alessio⁶^ORCID,Filiberti Serena⁷,Turati Marta⁷,Ronca Roberto⁷,Kopecka Joanna⁸,Riganti Chiara⁸^ORCID,Fionda Cinzia³,Bordone Rosa³,Della Rocca Giorgia³,Canettieri Gianluca³,Supuran Claudiu T.⁶^ORCID,Silvestri Romano²^ORCID,La Regina Giuseppe²^ORCID

Affiliation:

1. Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart, Largo Francesco Vito 1, Rome 00168, Italy

2. Laboratory Affiliated with the Institute Pasteur Italy─Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Roma 00185, Italy

3. Laboratory Affiliated to Istituto Pasteur Italia─Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, Rome 00161, Italy

4. Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States

5. Department of Biology and Biotechnologies “Charles Darwin”, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy

6. Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universitá degli Studi di Firenze, Via Ugo Schiff 6, Sesto Fiorentino I-50019, Firenze, Italy

7. Experimental Oncology and Immunology Unit, Department of Molecular and Translational Medicine, University of Brescia, Via Branze 39, Brescia 25123, Italy

8. Department of Oncology and Molecular Biotecnology Center “Guido Tarone″, Oncological Pharmacology Unit, Via Nizza 44, Torino 10126, Italy

Funder

National Cancer Institute

Ministero dell’Istruzione, dell’Università e della Ricerca

Sapienza Università di Roma

Associazione Italiana per la Ricerca sul Cancro

Fondazione Umberto Veronesi

Institute Pasteur Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01424

Reference79 articles.

1. Carbonic anhydrases

2. Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

3. The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families

4. Carbonic anhydrases as targets for medicinal chemistry