Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library-Reference-Cited by-同舟云学术

Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library

Published:2024 Issue:5 Volume:15 Page:1675-1685
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Yu Tao¹²,Zeng Rong²³,Guan Yu⁴,Pan Bin²,Li Hong-Wei²,Gu Jing²,Zheng Peng-Fei²,Qian Yan¹,Ouyang Qin²^ORCID

Affiliation:

1. Department of Pharmacy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China

2. Department of Medicinal Chemistry, Third Military Medical University, Chongqing 400038, China

3. Department of Gastroenterology, Xinqiao Hospital, The Second Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing 400037, China

4. College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, 643000, China

Abstract

Based on synthetic methodology-based library, a new class of tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors with excellent tumor multidrug resistance reversal activity was discovered.

Funder

National Natural Science Foundation of China

Third Military Medical University

Natural Science Foundation of Chongqing Municipality

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00136B

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