Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

Author:

Sinatra Laura1,Vogelmann Anja2,Friedrich Florian2,Tararina Margarita A.3ORCID,Neuwirt Emilia45ORCID,Colcerasa Arianna2,König Philipp6,Toy Lara7ORCID,Yesiloglu Talha Z.8,Hilscher Sebastian89ORCID,Gaitzsch Lena2ORCID,Papenkordt Niklas2ORCID,Zhai Shiyang6ORCID,Zhang Lin10ORCID,Romier Christophe11ORCID,Einsle Oliver10ORCID,Sippl Wolfgang8ORCID,Schutkowski Mike9ORCID,Gross Olaf4512,Bendas Gerd6ORCID,Christianson David W.3ORCID,Hansen Finn K.16ORCID,Jung Manfred2ORCID,Schiedel Matthias713ORCID

Affiliation:

1. Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany

2. Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany

3. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

4. Institute of Neuropathology, Medical Center−University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany

5. CIBSS−Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany

6. Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany

7. Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany

8. Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 2-4, 06120 Halle (Saale), Germany

9. Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany

10. Institute of Biochemistry, University of Freiburg, Albertstraße 21, 79104 Freiburg, Germany

11. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, 1 rue Laurent Fries, F-67400 Illkirch, France

12. Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany

13. Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany

Funder

European Commission

Agence Nationale de la Recherche

Université de Strasbourg

U.S. Department of Energy

Deutsche Forschungsgemeinschaft

French Infrastructure for Integrated Structural Biology

Verband der Chemischen Industrie

China Scholarship Council

U.S. Department of Health and Human Services

Instruct-ERIC

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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