Structure–Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD<sup>+</sup>-Dependent Lysine Deacylase Sirtuin 2-Reference-Cited by-同舟云学术

Structure–Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD⁺-Dependent Lysine Deacylase Sirtuin 2

Published:2024-06-07 Issue:12 Volume:67 Page:10076-10095
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Colcerasa Arianna¹,Friedrich Florian¹^ORCID,Melesina Jelena²,Moser Patrick¹,Vogelmann Anja¹³,Tzortzoglou Pavlos¹,Neuwirt Emilia⁴^ORCID,Sum Manuela⁵,Robaa Dina²,Zhang Lin⁶,Ramos-Morales Elizabeth⁷,Romier Christophe⁷^ORCID,Einsle Oliver⁶^ORCID,Metzger Eric⁵,Schüle Roland⁵³,Groß Olaf⁴,Sippl Wolfgang²^ORCID,Jung Manfred¹³^ORCID

Affiliation:

1. Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, Freiburg 79104, Germany

2. Department of Medicinal Chemistry, Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 4, Halle/Saale 06120, Germany

3. CIBSS─Centre for Integrative Biological Signalling Studies, Freiburg 79104, Germany

4. Institute of Neuropathology, University of Freiburg Medical Center, Breisacher Straße 113, Freiburg 79106, Germany

5. Department of Urology and Center for Clinical Research, University of Freiburg Medical Center, Breisacher Straße 66, Freiburg 79106, Germany

6. Institute of Biochemistry, University of Freiburg, Albertstraße 21, Freiburg 79104, Germany

7. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, 1 Rue Laurent Fries, Illkirch F-67400, France

Funder

European Research Council

Institut National de la Sant? et de la Recherche M?dicale

Universit? de Strasbourg

Deutsche Forschungsgemeinschaft

Centre National de la Recherche Scientifique

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00229

Reference86 articles.

1. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2. Histone deacetylases (HDACs): characterization of the classical HDAC family

3. Crystal structure analysis of human Sirt2 and its ADP-ribose complex

4. The Current State of NAD+-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination;Bulletin of the Korean Chemical Society;2024-09-03