Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology
Author:
Affiliation:
1. Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany
Funder
Deutsche Forschungsgemeinschaft
Baden-W??rttemberg Stiftung
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01153
Reference351 articles.
1. Proteomic analysis of post-translational modifications
2. Formation and Signaling Actions of Electrophilic Lipids
3. The molecular hallmarks of epigenetic control
4. Idiosyncratic Drug Reactions: Current Understanding
5. The resurgence of covalent drugs
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