Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway-Reference-Cited by-同舟云学术

Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway

Published:2024-09-11 Issue:1 Volume:39 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Liang Jinhao¹,Huang Jin¹,Yang Jianzhan¹,Liang Weihong¹²,Li Haoxiang¹,Wu Yunshan¹²,Liu Bo¹²³

Affiliation:

1. The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China

2. Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

3. State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

Funder

Natural Science Foundation of Guangdong Province

Science and Technology Program of Guangzhou

Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine

Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine

Special Funds for State Key Laboratory of Dampness Syndrome of Chinese Medicine

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2024.2390911

Reference37 articles.

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3. Rho GTPase regulatory proteins in podocytes

4. RhoA, RhoB and RhoC have different roles in cancer cell migration

5. Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration