Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1-Reference-Cited by-同舟云学术

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Published:2018-03-31 Issue:8 Volume:61 Page:3674-3684
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Durek Thomas¹^ORCID,Cromm Philipp M.¹²^ORCID,White Andrew M.¹^ORCID,Schroeder Christina I.¹,Kaas Quentin¹^ORCID,Weidmann Joachim¹,Ahmad Fuaad Abdullah¹,Cheneval Olivier¹,Harvey Peta J.¹,Daly Norelle L.¹^ORCID,Zhou Yang³,Dellsén Anita⁴,Österlund Torben⁵⁶,Larsson Niklas⁵,Knerr Laurent⁷^ORCID,Bauer Udo⁷,Kessler Horst²^ORCID,Cai Minying³^ORCID,Hruby Victor J.³,Plowright Alleyn T.⁷,Craik David J.¹^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

2. Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany

3. Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States

4. Mechanistic Biology & Profiling, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg 43183 Sweden

5. Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg 43183 Sweden

6. Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg 43183 Sweden

7. Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg 43183 Sweden

Funder

Deutscher Akademischer Austauschdienst

National Health and Medical Research Council

Deutsche Forschungsgemeinschaft

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00170

Reference45 articles.

1. Anatomy and regulation of the central melanocortin system

2. MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors

3. Melanocortins As Innovative Drugs for Ischemic Diseases and Neurodegenerative Disorders: Established Data and Perspectives

4. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

5. Design of novel melanocortin receptor ligands: Multiple receptors, complex pharmacology, the challenge

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