Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925-Reference-Cited by-同舟云学术

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925

Published:2018-03-20 Issue:7 Volume:61 Page:3089-3113
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Conroy Sean¹,Kindon Nicholas D.¹,Glenn Jacqueline²³,Stoddart Leigh A.²³,Lewis Richard J.⁴,Hill Stephen J.²³,Kellam Barrie¹³^ORCID,Stocks Michael J.¹^ORCID

Affiliation:

1. School of Pharmacy, Centre for Biomolecular Sciences, University Park Nottingham, Nottingham NG7 2RD, U.K.

2. Division of Physiology, Pharmacology & Neuroscience, Medical School, University of Nottingham, Nottingham NG7 2UH, U.K.

3. Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, the Midlands NG7 2UH, U.K.

4. Medicinal Chemistry, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Mölndal, Gothenburg 431 83, Sweden

Funder

Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00139

Reference31 articles.

1. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

2. Is there a basis for distinguishing two types of P2-purinoceptor?

3. Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate

4. Drug-like Antagonists of P2Y Receptors—From Lead Identification to Drug Development

5. Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

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